Legumes for Organic Cropping Systems

A field experiment which focuses on the yield performance of both durum wheat and sunflower included in a twoyear rotation between wheat/subterranean clover and sunflower was carried out in an organic farm in Central Italy. Three factors were included in the experiment according to a factorial design: a) two different previous crop sequences (four years of alfalfa, four years of annual crops); b) three fertilization levels (without and with animal manure incorporated at 15 or 40 cm depth); c) three durum wheat genotypes (Appulo, Arcangelo and Daunia cvs). The results obtained show that a previous alfalfa meadow allows the succeeding crops (wheat and sunflower) to achieve an appropriate and stable grain yield (about 4 and 3 t ha-1, respectively) even without organic manure for two consecutive cycles. When the durum wheat follows an annual crop sequence, grain yield appears unstable and the different levels of organic fertilizer determine a negative effect in the first cycle and a positive effect in the second cycle. The reseeding capability of sunflower was reduced by animal manure treatments and, consequently, the subclover biomass and its nitrogen content were generally lower in fertilized plots. Anyway, subclover biomass, which was ploughed in after reseeding as a green manure for sunflower, proved to be effective in stabilizing sunflower grain yield, especially in plots without any organic fertilization

Dr. Favalli, et al. reply

We thank Dr. So, et al1 for the interest in our letter2 and for sharing the results about the coronavirus disease 2019 (COVID-19) in patients with systemic lupus erythematosus (SLE) in Hong Kong1 We agree that the quantification of the risk of infection with severe acute respiratory coronaviruses-2 (SARS-CoV-2) in patients with SLE is a major concern

Alternative Cropping Systems with Self Reseeding Annual Legumes in a Mediterranean Environment

Self-reseeding winter annual legumes (subclover and snail medic) have the potential to induce a significant shift towards a less energy-intensive and more environmentally friendly management in the modern and specialized cereal cropping systems. Nevertheless their use is practically unknown in mixed stands with winter cereals, where they can contribute to supply nitrogen and to reduce herbicides input. We conceived an alternative cropping system where an annual legume performs, respectively, as living mulch in a winter cereal (winter wheat), as a cover crop after reseeding and as dry mulch for the succeeding summer cereal (corn). Trials carried out at the Tuscia University (Central Italy) in the period 1995-1997 showed that almost all the tested legumes cultivars were able both to grow sufficiently as a living mulch in the wheat and to provide a good re-establishment and an abundant mulch after the wheat harvest for the next corn. Trifolium yanninicum cv Trikkala and Trifolium subterraneum cvs Karridale and Mount Barker ranked first in reseeding capacity (up to 400 seedlings m-2) and mulch production (up to 5 t ha-1). No difference in grain yield between wheat with a living mulch and wheat in pure stand was found when legumes, such as Trifolium yanninicum cvs Trikkala and Larisa, Trifolium brachycalycinum cv Clare, Trifolium subterraneum cv Nungarin and Medicago scutellata cv Kelson, were grown in binary mixture with wheat. The aboveground biomass production of the succeeding irrigated corn crop was largely dependent on the amount of legume dry mulch left upon the ground

Il Trattato teologico-politico di Spinoza, tra filosofia e militanza

Peculiarit\ue0 del Trattato teologico-politico di Spinoza tra elaborazione teorica e impegno militante, nella contingenza storica olandese

Randomized controlled trials and real-world data : differences and similarities to untangle literature data

Randomized controlled trials (RCTs) represent the gold-standard of medical evidence to assess the efficacy and safety of therapeutic interventions. However, the need to minimize bias and ensure the correct design to explore the study aims often affects the generalizability of results. As a consequence, the evidence derived from the most rigorous research strategy available is not always representative of the real-world settings for which this evidence is ultimately intended. Observational studies, in contrast, although affected by a number of potential confounders, can more effectively capture treatment characteristics and safety issues that had not been identified by previous RCTs, owing to the short duration of follow-up or highly selective inclusion criteria. The aim of this review is to provide a comparative summary of the main advantages and pitfalls of RCTs and real-world data, emphasizing the need for a constant integration of all available levels of evidence to provide the best care for patients

COVID-19 revisiting inflammatory pathways of arthritis

Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by severe acute respiratory syndrome coronavirus 2, which predominantly affects the lungs and, under certain circumstances, leads to an excessive or uncontrolled immune activation and cytokine response in alveolar structures. The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1\u3b2 or TNF or targeting cytokine signalling via Janus kinase inhibition in the treatment of COVID-19. Despite these similarities, COVID-19 and other zoonotic coronavirus-mediated diseases do not induce clinical arthritis, suggesting that a local inflammatory niche develops in alveolar structures and drives the disease process. COVID-19 constitutes a challenge for patients with inflammatory arthritis for several reasons, in particular, the safety of immune interventions during the pandemic. Preliminary data, however, do not suggest that patients with inflammatory arthritis are at increased risk of COVID-19